The aim of the current work proposed to utilize food by-products through an integrated process of solid-state (SsF) and submerged fermentation (SmF) with the purpose of obtaining the target compound itaconic acid (IA). Initially, this process was applied to glucose as substrate, which was also considered a control experiment. Through SsF with Aspergillus awamori, the production of hydrolytic enzymes (cellulase and glucoamylase) was obtained, and these were applied in SmF with A. terreus to produce IA. IA is a 5-C unsaturated organic acid highly used in producing biopolymers and with several positive qualities