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The Peculiarities of Circadian Rhythms and Their Implications on Parkinson’s Disease

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dc.contributor.author ROTARU, Lilia
dc.contributor.author CEBUC, Mădălina
dc.contributor.author LUPUŞOR, Adrian
dc.contributor.author GROSU, Oxana
dc.contributor.author VOVC, Victor
dc.contributor.author LOZOVANU, Svetlana
dc.contributor.author CĂRĂUŞUL, Ghenadie
dc.contributor.author GROPPA, Stanislav
dc.date.accessioned 2023-11-15T11:50:47Z
dc.date.available 2023-11-15T11:50:47Z
dc.date.issued 2023
dc.identifier.citation ROTARU, Lilia, CEBUC, Mădălina, LUPUŞOR, Adrian et al. The Peculiarities of Circadian Rhythms and Their Implications on Parkinson’s Disease. In: 6th International Conference on Nanotechnologies and Biomedical Engineering: proc. of ICNBME-2023, 20–23, 2023, Chisinau, vol. 2: Biomedical Engineering and New Technologies for Diagnosis, Treatment, and Rehabilitation, 2023, p. 362-371. ISBN 978-3-031-42781-7. e-ISBN 978-3-031-42782-4. en_US
dc.identifier.isbn 978-3-031-42781-7
dc.identifier.isbn 978-3-031-42782-4
dc.identifier.uri https://doi.org/10.1007/978-3-031-42782-4_39
dc.identifier.uri http://repository.utm.md/handle/5014/24823
dc.description Acces full text - https://doi.org/10.1007/978-3-031-42782-4_39 en_US
dc.description.abstract Unsettling epidemiological data suggest Parkinson’s disease as the second most common neurodegenerative disorder worldwide. The worries persist as there is a demographic tendency towards the ageing of the population as the life expectancy rises. Simultaneously, circadian rhythm disruptions become more frequent as artificial life sources multiply in our daily lives. Thus, the interest of this study resides in determining the traits the endogenous clock has in the context of Parkinson’s. In order to reach this aim, a case control approach was selected which helped identify the associations between altered sleep quality and the disease (p = 0.007) along with the worsening of the motor dysfunctions (p = 0.029). Additionally, chronotype based variances in symptomatology’s severity was observed – worst outcomes remarked in morning individuals. Furthermore, the effect light, as main zeitgeber, exerts in diagnosed subjects was assessed and completed with from complementary studies evaluating its uses as a therapeutic tool. The end point of this paper was to attract attention upon an insufficiently researched topic, as are circadian rhythms disruptions in Parkinson’s disease, since they only recently acquired a diagnostical relevance as prodromal non-motor symptoms. Correspondingly, we wanted to incite researchers from different fields to study ways of using the biological clock’s peculiarities to enhance diagnosed patients’ lives through a transdisciplinary approach. en_US
dc.language.iso en en_US
dc.publisher Springer Nature Switzerland en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject circadian rhythms en_US
dc.subject Parkinson’s disease en_US
dc.subject chronotype en_US
dc.subject sleep en_US
dc.title The Peculiarities of Circadian Rhythms and Their Implications on Parkinson’s Disease en_US
dc.type Article en_US


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  • 2023
    6th International Conference on Nanotechnologies and Biomedical Engineering, September 20–23, 2023, Chisinau, Moldova

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Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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