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Antibacterial Activity of "Green" Silver Nanoparticles (AgNPs) in Combination with Benzylpenicillin and Kanamycin

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dc.contributor.author OHANYAN, Seda
dc.contributor.author RSHTUNI, Lilit
dc.contributor.author HOVHANNISYAN, Ashkhen
dc.date.accessioned 2023-11-10T07:12:09Z
dc.date.available 2023-11-10T07:12:09Z
dc.date.issued 2023
dc.identifier.citation OHANYAN, Seda, RSHTUNI, Lilit, HOVHANNISYAN, Ashkhen. Antibacterial Activity of "Green" Silver Nanoparticles (AgNPs) in Combination with Benzylpenicillin and Kanamycin. In: 6th International Conference on Nanotechnologies and Biomedical Engineering: proc. of ICNBME-2023, 20–23, 2023, Chisinau, vol. 1: Nanotechnologies and Nano-biomaterials for Applications in Medicine, 2023, p. 537-545. ISBN 978-3-031-42774-9. e-ISBN 978-3-031-42775-6. en_US
dc.identifier.isbn 978-3-031-42774-9
dc.identifier.isbn 978-3-031-42775-6
dc.identifier.uri https://doi.org/10.1007/978-3-031-42775-6_57
dc.identifier.uri http://repository.utm.md/handle/5014/24744
dc.description Acces full text - https://doi.org/10.1007/978-3-031-42775-6_57 en_US
dc.description.abstract Our study involved testing the antibacterial activity of biogenic AgNPs and their complexes with the antibiotics benzylpenicillin (BP) and kanamycin (KM) against the growth of the gram-negative bacteria Escherichia coli K-12. The antibacterial activity of preparations studied with the disk diffusion method, determined the colony-forming activity by serial dilutions, and calculated the minimum inhibitory concentrations (MIC) of the preparations. Additionally, we determined the growth phases of Escherichia coli K-12. Our findings indicate that the AgNPs at the studied concentrations do not possess cyto- and genotoxicity. The results showed that the action of AgNPs in combination with BP against the growth of the bacterium Escherichia coli K-12 has a synergistic effect at concentration 0.5 mg/ml and higher, which can reduce the antibiotic dose up to 8 times, while in the complex with KM has additive activity, in this case, AgNPs reduce the active dose of KM by 30 times. The tested complexes have potential antivirulence effects that inhibiting the development of biofilm formation at concentrations below the MIC. These findings suggest that the complexes could be used as safe alternatives to antibiotics. en_US
dc.language.iso en en_US
dc.publisher Springer Nature Switzerland en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject green silver nanoparticles en_US
dc.subject escherichia coli K-12 en_US
dc.subject benzylpenicillin en_US
dc.subject kanamycin en_US
dc.subject antibacterial biocompatible complexes en_US
dc.title Antibacterial Activity of "Green" Silver Nanoparticles (AgNPs) in Combination with Benzylpenicillin and Kanamycin en_US
dc.type Article en_US


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  • 2023
    6th International Conference on Nanotechnologies and Biomedical Engineering, September 20–23, 2023, Chisinau, Moldova

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Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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