Dereglările perfuzionale în şocul hemoragic şi corecţia lor

Abstract

The present study has been undertaken in order to establish the characteristic traits of the structural disorders in the vital organs (liver, heart, kidney, intestines) during a period of 90 min of hemorrhagic shock reproduced on rabbits. Likewise, the effect of hyaluronic acid has been evaluated when glycoaminoglycane was administered for the shock resuscitation by the infusion of Ringer solution and hyaluronic acid. In the case of administration during infusional therapy the hyaluronic acid has improved the evolution of the reperfusion syndrome leading to less expansion of the structural damages. Hence, this glycoaminglycane can be an additional support for the resuscitation efficacy based on its availability to fortify the antioxidant potential, to attenuate the inflammatory response and to optimize the endothelium dependent on vascular reactivity. Being an important component of extracellular matrix the hyaluronic acid reduces the risk of cell degradation, of the interstitial proteins and of the apoptosis induced caspases activities improving likewise the phenomena linked with blood flow redressing such as reperfusion syndrome and non reflow repercussion